The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by the study of three-dimensional structures of macromolecules, using crystallography and cryo- electron microscopy. These methods are integrated by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes understanding the reactivity of flavoenzymes with oxygen (Mattevi), extracellular systems involved in signal transduction and in ECM assembly (Forneris), enzymes of the neurotransmitter metabolism (Binda), membrane proteins (Magnani), and protein complexes involved in chromatin remodeling (Mattevi).
13/11/2020 - New Publication
Two new publications. Luca Iacovino et al reveal the structural basis for the rotation mechanism underlying sugar epimerisation as published in Journal of Biological Chemistry. In a joint paper with the lab of Piet Gros in Utrecht, Wout Oosterheert et al report a thorough analysis of the elegant helical fold of the of NOX-STEAP family in < href="https://doi.org/10.1021/acs.accounts.0c00400" target="_blank">Accounts of Chemical Research. - Browse the publications of our groups.
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)< br>