News
08/09/2024 - New publications
Thanks to the wonderful collaboration with the group of Phil Cole (Harvard), we studied the mechanisms underlying the crosstalk between two or more histone modifications in a epigenetic enzyme. See the original article in Nature Chemical Biology and the related News & Views. You are also welcome to look at the News & and Views published in Nature Catalysis on our work on coenzyme Q biosynthesis. To know about the intricacy and beauty of oxidative reactions in natural product biosynthesis, look at our review published in Biochemistry. - Browse the publications of our groups.
20/05/2024 - Two new publications
Our work on the biosynthesis of two essential cofactors is published! The article in Nature Catalysis unveils the mitochondrial metabolon that generates coenzyme Q10. Nature Communications describes the evolution of vitamin C biosynthesis. - Browse the publications of our groups.
16/11/2023 - Two new publications
The first in-class inhibitors of NADPH oxidases are reported in Nature Chemical Biology thanks to the fantastic work of Joana, Marta and Sara and the collaboration with Haribabu Arthanari, at the Harvard Medical School. We also published in ACS Catalysis on new enzymatic transformations of aromatic building blocks together with Marco Fraaije's group. - Browse the publications of our groups.
18/05/2023 - Quite some news!
The Mattevi group has been awarded an ERC Advanced grant that will investigate how enzymes jointly operate in the cell. Exciting science ahead!
15/04/2023 - New publication
Together with our friends in Groningen Maria Laura Mascotti and Marco Fraaije, we published a Nature Communications paper on the evolution of a drug-detoxifying enzymatic system. - Browse the publications of our groups.
31/03/2023 - Upgrades
We acquired new equipment, including mass photometry through the PNRR INF-ACT project.
20/01/2023 - A good start
Our group joined the EU-H02020 RISE training network B-LigZymes, led by Ligia Martins in Lisbon. Also have a look at the commentary just published in PNAS on the newly revealed unexpected structure of the mycobacterial pyruvate dehydrogenase. - Browse the publications of our groups.
03/09/2021 - New Publication
Congratulations to Laura Rotilio for her paper in ACS catalysis on a new and promising peroxygenase. - Browse the publications of our groups.
12/05/2021 - New Publication
You are welcome to look at the commentary on Baeyer Villiger enzymes, published the 60th Anniversary Issue special issue of Biochemistry. - Browse the publications of our groups.
17/03/2021 - New Publication
Two new publications. Bailleul et al present the new results secured by applying ancestral reconstruction methods to characterize FMO1, published in Journal of Biological Chemistry. In addition, our new commentary from Massari et al, also in the Journal of Biological Chemistry, comments on the fine mechanisms of electron transfer in the electron transfer flavoprotein EtfAB from the anaerobic gut bacterium Acidaminococcus fermentans. - Browse the publications of our groups.
13/11/2020 - New Publication
Two new publications. Luca Iacovino et al reveal the structural basis for the rotation mechanism underlying sugar epimerisation as published in Journal of Biological Chemistry. In a joint paper with the lab of Piet Gros in Utrecht, Wout Oosterheert et al report a thorough analysis of the elegant helical fold of the of NOX-STEAP family in < href=https://doi.org/10.1021/acs.accounts.0c00400 target=_blank>Accounts of Chemical Research. - Browse the publications of our groups.
22/07/2020 - New Publication
Francesca Magnani contributed to the the development of a new angiotensin receptor peptide agonist with enhanced stability in serum compared to the parent compound. Moreover, the novel analogue discriminates between the 2 angiotensin receptors that are characterised by opposing biological functions, binding more tightly the Angiotensin type-2 receptor with consequent neurotrophic effect.. Full story published on Chemistry - A European Journal. - Browse the publications of our groups.
03/07/2020 - New Publication
A sinergy between the Binda team and a group at INSERM Toulouse allowed to apply an enzymology combined to cell biology approach to study the role of Monoamine Oxidase A in ROS production in the heart and in cardiac ageing. Full story published on ACS Chem Biol. - Browse the publications of our groups.
29/05/2020 - New Publication
A unlikely light reaction biochemical reaction revealed by our joint Nature Communications paper with the group in Munster Browse the publications of our groups.
18/05/2020 - First online SMARTBOX meeting
This H2020 project is funded by the Bio-Based Industries Joint Undertaking (BBI JU), a public-private partnership between the European Union (H2020 program) and the Bio-based Industries Consortium (BIC). Within SMARTBOX, eleven participants from eight European countries will work together to develop innovative ways of transforming biomass into added-value bio-aromatics. Our contribution consists in engineering and characterize effective biocatalysts under a biochemical and structural point of view.
01/04/2020 - New Publication
New publication in eLife, Proteins can be stabilised to stand boiling water! Browse the publications of our groups.
17/02/2020 - New Publication
New publication in Redox Biology, describing novel insight on the inhibition on NADPH oxidases (NOXs). Browse the publications of our groups.
02/01/2020 - A good start of the New Year – new publications and more!
Andrea Alfieri, who will be in charge of the cryoEM facility, has just published an article in PNAS where he describes the mechanism of ligand selectivity in plant glutamate receptors, a landmark result in the field. Callum R. Nicoll, our Oxytrain PhD fellow, published an article in Nature Structural & Molecular Biology, where the structure and evolution of the flavin-containing monooxygenases, a key system in human drug metabolism, are described. See also the News and Views preview by Phillips & Shephard. And last but not least, the 200 kV cryo-electron microscope has been delivered to our Department! Browse the publications of our groups.
09/12/2019 - New Publications
Congratulations to our former PhD fellows Elisa Millana and Simone Savino for publishing their PhD work in FEBS J and Nature Catalysis. Browse the publications of our groups.
30/07/2017 - Poster Award
Congratulations to Callum Nicoll for the Knowles award for Best Poster obtained at the “Enzyme, Coenzymes & Metabolic Pathways ” Gordon Research Conference 2019.
09/05/2019 - New Publication
New publication in Current Opinions in Structural Biology, reviewing the structures and mechanisms of ROS generation by NOX proteins. Browse the publications of our groups.
16/04/2019 - New Publication
New publication in Current Opinions in Chemical Biology, reviewing development of hybrid histone deacetylase inhibitors for cancer treatment. Browse the publications of our groups.
09/04/2019 - New Publication
New publication in Cell Reports, describing the cryo-EM characterization of the LSD2-NPAC-Nucleosome multimeric complex. Browse the publications of our groups.
12/02/2019 - New Publication
New publication in Protein Science, describing the crystal structure and the biochemical characterization of the third SRCR domain of murine Neurotrypsin. Browse the publications of our groups.
05/02/2019 - SiMPLOD
A structure-integrated curated online database of PLOD mutations, from Federico's group, is now online at http://fornerislab.unipv.it/SiMPLOD. An accompanying publication in The Journal of Bone and Mineral Research, describes the idea behing the database and its functionality. Browse the publications of our groups.
17/11/2018 - New Publication
New publication in Biochemistry, describing crystal structures of bacterial class I P450 enzymes CYP153s. - Full-text Download. Browse the publications of our groups.
31/10/2018 - Fellowship to Joana
Congratulations to Joana Reis, postdoc in our lab, who got an iCARE-2 fellowship, funded by AIRC and the European Union's Horizon 2020 research and innovation programme under the Marie Sk?odowska-Curie grant agreement for the next three years!
17/10/2018 - New Publication
New publication in Mol Membr Biol, describing strategies to engineer stability in NOX membrane enzymes. Browse the publications of our groups.
08/08/2018 - New Publication
New publication in Nature Communications, describing the three-dimensional architecture of multifunctional human collagen lysyl hydroxylase and glycosyltransferase LH3. - Press release on UniPV News Website (in Italian) - Press release on Fondazione Cariplo Website (in Italian). Browse the publications of our groups.
04/06/2018 - Poster Award
Congratulations to Marta Ceccon and the NOX group for the Best Poster award obtained at the “Biological roles of NADPH Oxidases: Insights into fundamental mechanisms and therapeutic potential” Gordon Research Seminar, Les Diablerets, Switzerland (26-27 May 2018) , with a poster titled: Biochemical and structural characterization of the NADPH Oxidase NOX5”.
10/03/2018 - Poster Award
Congratulations to Francesca Magnani and the NOX group for the Best Poster award obtained at the “Ligand recognition and molecular gating” GRC conference, Ventura, California (4-9 March 2018), with a poster titled: Crystal structures and atomic model of NADPH oxidase”.
13/01/2018 - New Publication
New publication in Chemical Reviews, describing the variety of mechanisms adopted by flavoenzymes to activate molecular oxygen. Browse the publications of our groups.
04/01/2018 - New Publication
New Nature Communications paper, describing development and usage of dual histone deacetylase and demethylase inhibitors to target the LSD1-CoREST-HDAC complex. Browse the publications of our groups.
13/09/2017 - EMBO Workshop
We are pleased to announce the EMBO workshop Enzymes, biocatalysis and chemical biology: The new frontiers, which will take place in Pavia, 09–12 September 2018.
03/09/2017 - New Publication
New ACS Chem Biol paper, describing implications of FMO5 in drug metabolism. Browse the publications of our groups. This article has received a recommendation from the Faculty of 1000.
31/07/2017 - New Publication
New JBC paper, describing new relevant features in vanillyl-alcohol oxidase. Browse the publications of our groups.
08/06/2017 - New Publication
New PNAS paper, describing the crystal structure of bacterial NOX5 fragments and implications of ROS production in various biological processes. Follow this link for a nice summary about NOX enzymes. Browse the publications of our groups.
08/06/2017 - New Publication
New ChemCatChem paper, describing new biocatalytic reactions for chemical synthesis of ketoisophorone, a result achieved through the ROBOX network. Browse the publications of our groups.
11/03/2017 - New Publication
New TiBS review describing new mechanisms for flavoproteins as covalent catalysts. Browse the publications of our groups.
16/02/2017 - Cryo-EM School
We are pleased to announce the 2017 edition of the Italian Association for Crystallography (AIC) International Crystallography School (AICS2017). This year's school title will be Bridging the gap between cryo-EM and crystallography. The school will be held in Pavia, Italy, from 3 to 6 September 2017.
14/02/2017 - PhD Position
Our group is part of the OXYTRAIN Marie Curie PhD Program, and positions are available!
16/01/2017 - Seminar
On Thursday Jan 26th, at 12:00 AM (Aula Buzzati-Traverso), we will host the seminar of Prof. Dario Neri (ETH Zurich), titled From encoded combinatorial libraries to targeted therapeutics.
27/12/2016 - New Publication
New JACS paper describing the biochemical and structural properties of a novel fungal Bayer-Villiger Monoxygenase. Browse the publications of our groups.
22/11/2016 - New Publication
New Angewandte Chemie International Edition paper describing the biochemical and structural characterization of TmCHMO. Browse the publications of our groups.
21/11/2016 - New Multimedia Contents
Our Movies and Data Section contains new movies and infographics about our latest discoveries.
10/11/2016 - New Publication
New BBRC paper describing the distinguishing features of recombinant human dihydroxyacetonephosphate acyl-transferase. Browse the publications of our groups.
28/10/2016 - Seminar
On Friday November 4th, at 10:00 AM (Aula Falaschi), we will host the seminar of Nancy Gray Ray (President and Chief Executive Officer of Gordon Research Conferences), titled Non-traditional science career.
17/10/2016 - Seminar
On Friday October 21st, at 2:30 PM (Aula Buzzati-Traverso), we will host the seminar of Dr. Fabrizio Martino (CIB Madrid), titled High-resolution structure investigation of protein complexes bound to the nucleosome core particle.
09/09/2016 - New Publication
New Science Advances paper describing two new classes of non-covalent LSD1 inhibitors with highly unusual structural features. Watch the Movie related to our paper - Browse the publications of our groups.
30/07/2016 - New Publication
New Current Opinions in Structural Biology review describing the structural and functional complexity of histone demethylase LSD1. Browse the publications of our groups.
29/07/2016 - New Publication
New Nature Protocols paper describing protocols and advice are given on how to develop thermostability assays for membrane proteins and how to combine mutations to make an optimally stable mutant suitable for structural studies. Browse the publications of our groups.
20/07/2016 - New Publication
New Nature Communications paper describing the discovery of a new post-Golgi trafficking pathway for the enzyme LH3/PLOD3 critical for collagen homeostasis. Browse the publications of our groups.
07/07/2016 - Seminars
On Tuesday Jul 12th, we will host the seminars of Prof. Mauro Gemmi (IIT Pisa), titled Electron diffraction as a tool for solving the crystal structure of organic molecules: from pharmaceuticals to proteins, and the seminar from Prof. Filippo Mancia (Columbia University, NY), titled Cryo-EM structure of the STRA6 receptor for retinol uptake.
24/05/2016 - Seminar
On Monday June 6th, at 3:00 PM (Aula Buzzati-Traverso), we will host the seminar of Dr. Arjen J. Jakobi (EMBL Heidelberg), titled Challenges for high-resolution 3D cryo-EM of macromolecular complexes: a case study of RNA Pol III and TMV.
21/04/2016 - New Publication
New Hum Mol Gen paper describing the biochemical and structural characterization of pathogenic mutations of LSD1/KDM1a associated to a form of intellectual disability. Browse the publications of our groups.
11/04/2016 - Seminars
On Friday Apr 29th, we will host the seminars of Prof. Stefano Piccolo (Univ. Padova), titled Role of YAP/TAZ in stem cells and cancer, and the seminar from Prof. Daniela Rhodes (NTU Singapore), titled Telomerase and the role of G-quadruplexes in biology.
11/04/2016 - Seminar
Next Friday Apr 15th, at 1:00 PM (Aula Buzzati-Traverso), we will host the seminar of Dr. Jean-Nicholas Longchamp (Univ. Zurich), titled Enabling structural biology at the truly single molecule level.
25/03/2016 - New Publication
New EMBO J paper showing the three-dimensional structures of human and viral complement regulators. Browse the publications of our groups.
24/03/2016 - New Publication
New Proteins paper describing the three-dimensional structure of 7beta-hydroxysteroid dehydrogenase. Browse the publications of our groups.
20/01/2016 - New Publication
New EMBO J review describing the mechanisms of interactions between protein regulators and nucleosomes. Browse the publications of our groups.
16/01/2016 - New Publication
New ACS Chem Biol paper describing the discovery of FMO5 as an enzyme catalyst for Baeyer-Villiger reactions in Humans. Browse the publications of our groups.
03/07/2015 - Valentina Piano got a fellowship
We wish to send our warmest congratulations to Valentina Piano, postdoc in our lab, who got a 1-year FIRC-AIRC (Italian Foundation for Cancer Research) Fernando Giampaolo Gnudi e Chiarina Ventura Fellowship.
01/09/2015 - New Publication
New ACS Chem Biol paper describing new inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents. Browse the publications of our groups.
03/07/2015 - Valentina Speranzini got the Young Investigator Chiara D'Onofrio prize
We wish to send our warmest congratulations to Valentina Speranzini, postdoc in our lab, who got the young investigator Chiara D'Onofrio Prize for her oral presentation at SIBBM 2015!
06/03/2015 - Lab Retreat
Our yearly lab retreat is coming soon! From Thursday, March 25th, to Saturday, March 27th, our groups and collaborators will gather at Park Hotel Olimpia at Brallo di Pregola for networking, excellent science, and good food!
17/02/2015 - New Publication
New PNAS paper describing how, using SAXS and biophysics, we elucidated the interactions among the LSD1-CoREST complex, the histone H3 tail and the DNA. Watch the Movie related to our paper - Browse the publications of our groups.
27/01/2015 - New Publication
New ACS Med Chem Lett describing new enzyme selectivity and in-cell studies on Tranylcypromine-based LSD1 inhibitors. Browse the publications of our groups.
23/12/2014 - Best wishes for the New Year
The last month has been very fruitful in term of fund raising and we expect several pre- and post-doctoral open positions on various projects in the next few months.
05/12/2014 - New Publication
New J. Am. Chem. Soc. article describing how to turn a Baeyer-Villiger Monooxygenase into a NADPH Oxidase. Browse the publications of our groups.
05/12/2014 - Seminar
On Dec 22nd, at 2:15 PM, there will be a seminar from Dr. F. Mancia, titled Exploring Membrane Protein Landscape: Experience from the New York Consortium on Membrane Protein Structure (NYCOMPS). Seminar Flyer.
03/12/2014 - Seminar
On Dec 4th, at 4:15 PM, there will be a seminar from Dr. L. Tamagnone, titled Semaphorin signalling controlling cancer cells and the tumour microenvironment. Seminar Flyer.
03/12/2014 - PhD Defenses
On Dec 19th, starting at 09:30 AM, The IUSS PhD candidates will defend their theses. The event will be held at the University of Pavia/Institute for Superior Studies (IUSS), in Piazza Vittoria.
03/11/2014 - New PhD Students
Martina Palamini and Nguyen Quoc-Thai joined Federico's and Andrea's reasearch teams, respectively, as PhD Students with University of Pavia/Institute for Superior Studies (IUSS) PhD fellowships.
15/10/2014 - Application Note Published
Our PhD fellow Valentina Speranzini published an application note on the usage of our ClarioStar Plate Reader titled Protein-Ligand binding measurements using fluorescence polarization. Link to the Application Note.
01/09/2014 - New Publication
New Eur J Med Chem article describing 1-substituted cyclopropylamine derivatives as irreversible inhibitors of histone demethylase LSD1. Browse the publications of our groups.
25/07/2014 - Nobel Prize Lecture
On September 4th, at 6:00 PM, Venki Ramakrishnan, Nobel Prize in Chemistry 2009 for studies of the structure and function of the ribosome, will give a lecture about The use of recent advances in electron microscopy to study ribosome structures. Seminar Flyer.
15/05/2014 - Seminar
On June 3rd, at 3:00 PM, there will be a seminar about usage from Dr. N. Luzzietti, titled Some like it hot: Drug Analytics using MicroScale Thermophoresis. Seminar Flyer.
03/05/2014 - Welcome to New Postdoc
We wish to send our warmest welcome to Francesca Magnani, who joined Andrea's research team.
01/05/2014 - NMR Lectures
Prof. Annalisa Pastore will give a short course about biological NMR at our University during next week. This short course is part of the Master Course in Molecular Biology and Genetics. Course Flyer.
14/04/2014 - Lecture Material
The PDF files for the teaching lectures given by Prof. D.E. Edmondson during the Master Course in Molecular Biology and Genetics are available for download following this link.
03/04/2014 - Welcome to New Postdoc
We wish to send our warmest welcome to Kaouthar Dridi, who joined Federico's research team.
23/03/2014 - Lab Retreat
Our yearly lab retreat is coming soon! From Thursday, March 27th, to Saturday, March 29th, we will all gather at Agriturismo Cà del Monte for networking, excellent science, and good food!
16/02/2014 - New instrument in the lab
Installation of our new Clariostar Plate Reader has been completed and the new instrument is available to users.
10/02/2014 - New grant for Federico
Federico Forneris has been awarded the Programma Giovani Ricercatori Rita Levi-Montalcini grant. Through this grant his group will extend the investigation on important bio-medical targets of the neuromuscular junctions and establish new research infrastructure in our department. We all wish to congratulate with him!.
30/01/2014 - Seminar
Next Friday Feb 7th, at 1:00 PM, we will host the seminar of Dr. Francesca Magnani, titled Production of eukaryotic membrane proteins for structural studies.
14/01/2014 - New Website!
We are proud to present the new layout of our website, representing now the entire Division of Structural Biology of the Department of Biology and Biotechnology, University of Pavia. The division is composed of the research groups led by Prof. Andrea Mattevi, Dr. Claudia Binda, and Dr. Federico Forneris.
14/01/2014 - Crystallography School
The 1st European Crystallography School (part of the celebrations for the International Year of Crystallography) will be hosted in Pavia, from 28th Aug to 6th Sep, 2014. Deadline for registrations is 9th Feb, 2014. More info on the School Website.
19/12/2013 - Seminar
Dan Nomura from Berkeley is visiting our lab and will give a seminar on January 10th at 14:30
19/12/2013 - They are Doctors Now!
Congratulations to Giuseppe Ciossani and Christian Martinoli for successfully defending their PhD thesis!
12/12/2013 - New Publication
New J. Med. Chem article describing pan-histone demethylase inhibitors
28/11/2013 - New Publication
We published a new paper on ACS catalysis about Bayer-Villiger Monoxygenases
10/11/2013 - Flavo Symposium 2014
Andrea Mattevi confirmed to give a main lecture at the Flavin meeting 2014
05/11/2013 - New PhD Student
Olga Wachocka joins our lab as PhD student
24/10/2013 - We are Growing!
The new website of the structural biology group led by Federico Forneris is online, and Open Positions are available!
13/10/2013 - New Publication
Congratulations to Elena Battaglioli who led the joint study on LSD1 neurospecific variant, now published in J. Neurochemistry.
13/10/2013 - Sometimes they come back
We wish to say welcome back to our former PhD student Aristotele Karytinos, who rejoined our team for a postdoc.
01/10/2013 - Something new is coming up!
Federico Forneris, former PhD student in our lab, will establish his new group in 2014 in our Department with the support of a grant from the Armenise-Harvard Foundation.