The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by the study of three-dimensional structures of macromolecules, using crystallography and cryo- electron microscopy. These methods are integrated by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes understanding the reactivity of flavoenzymes with oxygen (Mattevi), extracellular systems involved in signal transduction and in ECM assembly (Forneris), enzymes of the neurotransmitter metabolism (Binda), membrane proteins (Magnani), and protein complexes involved in chromatin remodeling (Mattevi).
31/03/2025 - New project
A wonderful March 21st, as we had the kick off meeting of Comenze, a European Doctoral Network on enzyme biotechnology. Please visit The COMENZE Website to see the PhD opportunities that are offered including one in our laboratory.
09/04/2025 - New publications
You are always welcome to check out our latest publications. We contributed to the work led by Brian Liau (Harvard) and Ning Zheng (HHMI) on the mechanisms of a new protein degrader published in Nature. In ACS Chem Biology, we report on the sophisticated biosynthesis of sorbicillinoids whereas in Journal of Medicinal Chemistry we describe dual inhibitors that shut down NOXs and MAOs, two of the most powerful enzymatic sources of ROS.
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)< br>
