The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by the study of three-dimensional structures of macromolecules, using crystallography and cryo- electron microscopy. These methods are integrated by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes understanding the reactivity of flavoenzymes with oxygen (Mattevi), extracellular systems involved in signal transduction and in ECM assembly (Forneris), enzymes of the neurotransmitter metabolism (Binda), membrane proteins (Magnani), and protein complexes involved in chromatin remodeling (Mattevi).

Latest News:

16/11/2023 - Two new publications
The first in-class inhibitors of NADPH oxidases are reported in Nature Chemical Biology thanks to the fantastic work of Joana, Marta and Sara and the collaboration with Haribabu Arthanari, at the Harvard Medical School. We also published in ACS Catalysis on new enzymatic transformations of aromatic building blocks together with Marco Fraaije's group. - Browse the publications of our groups.

18/05/2023 - Quite some news!
The Mattevi group has been awarded an ERC Advanced grant that will investigate how enzymes jointly operate in the cell. Exciting science ahead!

Structural Biology @ UniPV
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)< br>

        Our work is funded by:

European Research Council    Bacterial Enzymes and Bioprocesses for Lignin Valorization (H2020 MSCA-RISE)    Progetti di Ricerca di Interesse Nazionale - Ministero dell’Università e della Ricerca    Fondo Integrativo Speciale per la Ricerca    Pan-European Network on Computational Redesign of Enzymes    NIH    Italian Association for Cancer Research (AIRC)    Fondazione Cariplo    Austian Centre for Industrial Biotechnology    EU Smartbox Project