The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by the study of three-dimensional structures of macromolecules, using crystallography and cryo- electron microscopy. These methods are integrated by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes understanding the reactivity of flavoenzymes with oxygen (Mattevi), extracellular systems involved in signal transduction and in ECM assembly (Forneris), enzymes of the neurotransmitter metabolism (Binda), membrane proteins (Magnani), and protein complexes involved in chromatin remodeling (Mattevi).
07/01/2025 - New publications
You are welcome to check out our latest publications. In the Journal of Biological Chemistry, we describe the evolution, mechanism, structure and inhibition of prenylcysteine oxidases, two human enzymes that take care of the metabolism of amino acids from prenylated protein degradation. Thanks to a wonderful collaboration with Francesca Aguilo in Umea, we studied and published in Nature Communications about the non-catalytic functions of the oxidative histone demethylase LSD1. In ACS Catalysis, we are reporting on our most recent work addressing a classic problem in enzymology: what makes the difference between an oxidase and a dehydrogenase? In Biochemistry, we highlight the amazing diversity of redox enzyme class in natural product biosyntheses. - Browse the publications of our groups.
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)< br>
