The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by the study of three-dimensional structures of macromolecules, using crystallography and cryo- electron microscopy. These methods are integrated by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes understanding the reactivity of flavoenzymes with oxygen (Mattevi), extracellular systems involved in signal transduction and in ECM assembly (Forneris), enzymes of the neurotransmitter metabolism (Binda), membrane proteins (Magnani), and protein complexes involved in chromatin remodeling (Mattevi).

Latest News:

20/01/2021 - A good start
Our group joined the EU-H02020 RISE training network B-LigZymes, led by Ligia Martins in Lisbon. Also have a look at the commentary just published in PNAS on the newly revealed unexpected structure of the mycobacterial pyruvate dehydrogenase. - Browse the publications of our groups.

Structural Biology @ UniPV
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)< br>

        Our work is funded by:

Epigen - Epigenomics Flagship Project    Italian Association for Cancer Research (AIRC)    Fondazione Cariplo    Austian Centre for Industrial Biotechnology    ROBOX - Expanding the Industrial Use of Robust Oxidative Biocatalysts for the Conversion and Production of Alcohols - An H2020 Project     OXYTRAIN is a EU-H2020 Training Program focusing on characterization of four major classes of oxygenases    EU Smartbox Project