The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by the study of three-dimensional structures of macromolecules, using crystallography and cryo- electron microscopy. These methods are integrated by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes understanding the reactivity of flavoenzymes with oxygen (Mattevi), extracellular systems involved in signal transduction and in ECM assembly (Forneris), enzymes of the neurotransmitter metabolism (Binda), membrane proteins (Magnani), and protein complexes involved in chromatin remodeling (Mattevi).
17/03/2021 - New Publication
Two new publications. Bailleul et al present the new results secured by applying ancestral reconstruction methods to characterize FMO1, published in Journal of Biological Chemistry. In addition, our new commentary from Massari et al, also in the Journal of Biological Chemistry, comments on the fine mechanisms of electron transfer in the electron transfer flavoprotein EtfAB from the anaerobic gut bacterium Acidaminococcus fermentans. - Browse the publications of our groups.
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)< br>