34a
Riunione Nazionale(34th “A. Castellani” Meeting of PhD students in biochemical sciences)
BRALLO DI PREGOLA (Pavia)
5-9 June 2023
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PROGRAM
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MONDAY, JUNE 5th, 2023
17.00-20.00 Registration & check-in
20.00
DINNER
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Hyaluronan journey from biological glue to
biological cue
Altered CaMKII-SMAD signalling and cell junctions
in a mouse model of osteogenesis imperfecta type XIV
CRISPR/CAS9-mediated UBC gene knockout in gastric cancer cell lines as a
potential therapeutic strategy
COFFEE BREAK
Chair:
10.50-11.10 Matteo
Prisinzano (Università
di Firenze)
Sphingosine 1-phosphate signaling axis mediates neuropeptide S-induced
invasion of endometriotic cells
Acid sphingomyelinase inhibition in GBA-dependent Parkin-son’s disease
in vitro models: protective or damaging effect?
Development of a strategy to inhibit human neutrophil elastase in COVID-19
patients
Identification
of a potential biomarker predicting the efficacy of therapies in cystic
fibrosis: downregulation of plasmatic matrix metalloproteinase 9
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Metabolomics and lipidomics: new
tools for dissecting Inherited Metabolic Disorders
Effect of the lipid environment on the F508del-CFTR rescue and stability
at the plasma membrane
Recovery of human type 2 diabetes beta cell function associates with
transcriptomic signatures that point to novel therapeutic targets
COFFEE BREAK
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17.00-18.00
BLITZ PRESENTATIONS (A) (5 min)
1
Ornella Xynomilakis (Università di Milano)
Endocannabinoids, eicosanoids and essential lipids: composition of human
milk compared to infant formula, a chance to improve infant formula
nutritional benefits
2
Giusi Sabatini (Università di Teramo)
The endocannabinoid system and Lactiplantibacillus (Lpb.) plantarum: a
connection involved in the autism spectrum disorder
3
Costanza Cicchi (Università di Firenze)
Effect of sustainable feeding strategy with olive oil pomace in Holstein
lactating cows on bioactive peptides derived from milk proteins
4
Lorenzo Casbarra (Università di Firenze)
Pathlay: a novel graphical server for -omics integration and
interpretation
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Chair:
Mitochondria and Clock-genes interplay: a Time to Sleep, a Time to Wake up
9.40-10.00
Matteo Amadei (Sapienza Università di Roma)
Genetic incorporation of dansylalanine in human ferroportin to probe the
alternating access mechanism of iron transport
10.00-10.20 Rachele Agostini (Università di Urbino)
Caveolin-1-overexpression stimulates extracellular vesicle secretion and
modulates tumor microenvironment in a model of rhabdomyosarcoma
COFFEE BREAK
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Chair:
Multiomics approaches for therapeutic developments in ataxia
telangiectasia
NRF2 activation by cysteine uptake as a mechanism of survival for
Triple-Negative Breast Cancer cells
Involvment of the enzyme nicotinamide N-methyltransferase in
proliferation, invasive capacity and chemosensitivity of human
osteosarcoma
Sirtuin 6 regulates the activation of the ATP/purinergic axis in
endothelial cells
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Chair:
From biological chemistry to molecular medicine
Intermittent hypoxia and mild cognitive impairment: from a new in vitro model to promising peripheral plasma biomarkers of cognitive decline
Dynamic changes in immunoproteasome complex assembly and capping with
regulatory particles in an in vitro model of senescing macrophages
COFFEE BREAK
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21.00-23.00 Serata caminetto
Prof. Giovanni Apolone Direttore
Scientifico dell’Istituto Nazionale dei Tumori
Prof. Lucio Luzzatto
Università degli Studi di Firenze
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THURSDAY, JUNE 8th, 2023
9.00-9.40
Prof.
Santina Bruzzone
(Università di Genova)
Therapeutic potential of targeting the NAD world
Monocytes - derived microvesicles as cargo to transfer antigens to target
cells
The C-type lectin CD93 regulates platelet activation induced by Par4
stimulation
10.50-11.10 Azza Anan Dabous (Università della Campania)
Novel probiotic formulation containing hydroxyectoine for the treatment of
IBD on enterocyte based in vitro model
Expanding the toolbox of ubiquitous promoters for gene therapy
Redox perturbation in the SARS-CoV-2 spike protein induced by thiol
molecules
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Iron-sulfur cluster assembly proteins: potential plant magnetoreceptors
COFFEE BREAK
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1
Faiza Abbas (Università di Urbino)
RBC-derived extracellular vesicles as a drug delivery system: flow
cytometric analyses and challenges
2
Maria Sofia Bertilacchi (Università di Pisa)
ACE2 signaling drives lung injury in lung bronchial epithelial cells: a
focus on a possible ACE2 nuclear fraction activity
3
Alessia Giglio (IUSS Pavia)
Engineered PLGS nanoparticles targeting the MET receptor for intracellular
delivery of verteporfin
4
Cecilia Masiero (Università di Pavia)
A new combined treatment for the dominant osteogenesis imperfecta
zebrafish model Chihuahua
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FRIDAY, JUNE 9th, 2023
Proteomics: one approach to answer many biological questions
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SCIENTIFIC AND ORGANIZING COMMITTEE
Paola Chiarugi
Claudia Martini
Raffaele Porta
Cesare Balduini
Vittorio Bellotti
Antonella Forlino
Sofia Giorgetti
Giampaolo Minetti
Chiara Paganini
Giampiero Pietrocola
Maria Enrica Tira
Francesca Tonelli
Mauro Torti
Livia Visai
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SCIENTIFIC AND ORGANIZING SECRETARIAT
Università degli Studi di Pavia
Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”
Laboratori di Biochimica
Via Agostino Bassi, 21 - 27100 PAVIA
E-mail: riundott@unipv.it - Homepage: http://www.unipv.it/bralweb
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