29^a Riunione Nazionale
"A. Castellani"
dei Dottorandi di Ricerca in
Discipline Biochimiche

SCIENTIFIC AND ORGANIZING COMMITTEE

Cesare Balduini

Vittorio Bellotti

Antonio Rossi

Ilaria Canobbio

Giampaolo Minetti

Massimo Aureli

Paola Corsetto

Maurizia Valli

Maria Enrica Tira

Mauro Torti

Simona Viglio

 SCIENTIFIC AND ORGANIZING SECRETARIAT

Università degli Studi di Pavia

Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”

Laboratori di Biochimica

Via A. Bassi, 21 - 27100 PAVIA

 Tel. 0382/987236 - Fax 0382/987240

E-mail: riundott@unipv.it  - Homepage: http://www.unipv.it/bralweb

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PROGRAM

MONDAY, JUNE 5^th, 2017

17.00-20.00 ARRIVAL AND REGISTRATION

20.00 DINNER

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TUESDAY, JUNE 6^th, 2017

8.50-9.00 OPENING OF THE MEETING

Chair: Cesare Balduini / Vittorio Bellotti

9.00-9.40 Prof. FULVIO DELLA RAGIONE (Università della Campania, Napoli)
CIP/Kip proteins and cell cycle regulation: a paradigm of intrinsically unstructured proteins

9.40-10.00 Margherita Maggioni (Università di Milano)
Role of the GM1 ganglioside oligosaccharide in Trka-mediated neuritogenenesis in mouse neuroblastoma cells

10.00-10.20 Emanuela Stampone (Università della Campania “L. Vanvitelli”, Napoli)
p57^Kip2 in cell biology: focus on its post-translational modifications

COFFEE BREAK

Chair: Margherita Maggioni

10.50-11.10 Ilaria Caon (Università dell’Insubria, Varese)
The long non coding RNA HAS2-AS1 regulates breast cancer cells aggressiveness through a molecular sponge effect

11.10-11.30 Raffaella Longo (Università di Milano)
Ablation of epigenetic modifier histone deacetylase 3 in adipose tissue highlights chromatin acetylation as integral part of metabolism

11.30-11.50 Vladan Milosevic (Università di Torino)
Wnt/c-myc/ABCB5 determines chemoresistance in cancer stem cells of malignant pleural mesothelioma

11.50-12.10 Chiara Cavallini (Università di Pisa)
Inhibition of integrin α5β1 and reactivation of p53 pathway: a multi-target approach against human glioblastoma cells

LUNCH

Chair: Chiara Carnemolla

15.00-15.40 Prof. MARCO GOBBI (Istituto Mario Negri, Milano)
Molecular transitions in biochemistry: Binding kinetics.

15.40-16.00 Giulia Mancini (Università di Milano)
Effects of sphingolipids on membrane chloride channel stabilization in bronchial epithelial cell lines: a new challenge for the cystic fibrosis therapy

16.00-16.20 Alessio Gamba (Università di Milano)
A subset of disease gene products causing locus heterogeneity are members of the same protein complex

COFFEE BREAK

17.00-18.30 POSTER PRESENTATION FOLLOWED BY POSTER VIEWING - SESSION A
Authors should place their posters on the provided boards and present them in front of the audience with 2-3 slides for a total of 5 min including discussion.

DINNER

21.00-23.00 Paola Crosetto and Massimo Aureli from the University of Milan together with three young Post-Doc Fellows will talk about:
Azienda o accademia: cosa scegliere dopo il dottorato?

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WEDNESDAY, JUNE 7^th, 2017

Chair: Emanuela Stampone

9.00-9.40 Prof. BARBARA CAMPANINI (Università di Parma)
Molecular transitions in biochemistry: Enzyme kinetics

9.40-10.00 Paolo La Rocca (Università di Milano)
Synthesis, purification and biological activity evaluation of some unsaturated sialic acid derivatives as sialidase inhibitors

10.00-10.20 Giulia Resmini (Università di Milano)
Prolyl hydroxylases (PHDS) synthetic inhibitors improve skeletal muscle differentiation

COFFEE BREAK

Chair: Andrea Mozzarelli

10.50-11.10 Elena Maresi (Università di Verona)
PLP-dependent enzymes as anti-toxoplasmosis drug target

11.10-11.30 Elena Antonini (Università di Urbino)
Antioxidant and antiproliferative activities of natural and synthetic avenanthramides

11.30-11.50 Matteo Miceli (Università di Milano)
Shedding new light on the endocannabinoid system: fluorescent assays for monoacylglycerol lipase (MAGL)

11.50-12.10 Suresh Velnati (Università del Piemonte Orientale, Novara)
Novel diacylglycerol kinase alpha inhibitors for X-linked lymphoproliferative disease 1 therapy

LUNCH

Chair: Massimo Aureli

15.00-15.40 Prof. STEFANO GIANNI (Università di Roma La Sapienza)
Molecular transitions in biochemistry: Folding kinetics

15.40-16.00 Roberto Spezzano (Università di Milano)
SCA38 pathology: study in the ELOVL5 KO mouse model and in patients

16.00-16.20 Monica Di Venere (Università di Pavia)
Proteomic approaches to investigate the protein profiles of salivary glands and ovary of the tick Ixodes ricinus and the relationship with its intracellular symbiont Midichloria mitochondrii

COFFEE BREAK

Chair: Giulia Mancini

16.50-17.10 Chiara Carnemolla (Università di Siena)
Characterization of osteogenesis imperfecta through functional proteomics

17.10-17.30 Francesca Tonelli (Università di Pavia)
Generation of recessive osteogenesis imperfecta zebrafish models using CRISPR-Cas9 system

DINNER

21.00-23.00 Prof. Silvia Garagna and Prof. Amedeo Santosuosso will discuss with the students on the topic:
La libertà della ricerca scientifica

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THURSDAY, JUNE 8^th, 2017

Chair: Mauro Torti

9.00-9.40 Prof. DANIELE CONDORELLI (Università di Catania)
Integrative genomics and transcriptomics in colorectal cancer

9.40-10.00 Giulia Riolo (Università di Siena)
Branched peptide theranostics and heparan sulfate proteoglycans: a critical interaction in cancer selective therapy

10.00-10.20 Matteo Gaglianone (Università di Genova)
N-linked glycosylation of mouse peripheral myelin

COFFEE BREAK

Chair: Paola Corsetto

10.50-11.10 Caterina Visconte (Università di Pavia)
Role of amyloid precursor protein APP in platelet functionality 

11.10-11.30 Silvia Pignani (Università di Ferrara)
Exploring chaperone-like compounds as innovative therapeutic strategy for Hemophilia B 

11.30-11.50 Nicole Ziliotto (Università di Ferrara)
Expression of coagulation pathways components in multiple sclerosis associated with chronic cerebrospinal venous insufficiency

11.50-12.10 Valeria Booz (Università di Genova)
Abscisic acid controls the release of insulin from β-cells, Glucagon-Like Peptide-1 from intestinal L-cells and glucagon from α-cells

LUNCH

Chair: Caterina Visconte

15.00-15.40 Prof. PAOLO SWUEC (Università di Milano)
Introducing a collaborative research centre for cryo-electron microscopy in Milan.

15.40-16.00 Jessica Rizzo (Università di Milano)
Evaluation of aspirin responsiveness in healthy subjects and essential thrombocythemia patients

16.00-16.20 Mattia Ferrarese (Università di Ferrara)
Specific factor IX mRNA and protein features favor drug-induced readthrough over recurrent nonsense mutations

16.20-16.50 Susanna Fiorelli (Università di Milano)
Oxidative stress and plaque instability: in vitro and in vivo study of patient with coronary artery disease

COFFEE BREAK

17.20-19.00 POSTER PRESENTATION FOLLOWED BY POSTER VIEWING - SESSION B
Authors should place their posters on the provided boards and present them in front of the audience with 2-3 slides for a total of 5 min including discussion.

DINNER

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FRIDAY, JUNE 9^th, 2017

Chair: Cesare Balduini

9.30-10.10 Prof. PAOLA CORSETTO (Università di Milano)
Nutrition and fasting in the prevention and treatment of cancer

10.15 CLOSING REMARKS

COFFEE BREAK and DEPARTURE

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POSTER SESSION A, TUESDAY, JUNE 6^th, h 17:00-18:30*

1. Mayra Rachele Zarone (Napoli): miR-125b induces an early activation of senescence in vitro models of multiple myeloma, followed by apoptosis activation. A new weapon to overcoming U266 cells resistance to zoledronic acid

2. Erika Di Biase (Milano): GM1 oligosaccharide as new pharmacological perspective in central nervous system damage

3. Elena Caravà (Varese): Vascular inflammation and extracellular matrix modifications

4. Rossella Costantini (Pavia): Towards the generation of an animal model of chondrodysplasia with joint dislocations gPAPP type

5. Francesca Grassi Scalvini (Milano): Analysis of human blastocoel fluid isolated from women aged < and ≥ 37 years by a proteomic approach

6. Alessandra Toti (Firenze): Tumor microenvironment: proteome characterization of ectosomes released by cancer cells and fibroblasts

7. Lavinia Ferrone (Firenze): Stromal induced regulation of lipid metabolism in prostate carcinoma cells

8. Roberta Cavagna (Milano): Innovative, capture-based next generation sequencing (NGS) approach for immunoglobulin/T cell receptors clonal markers identification in adult acute lymphoblastic leukemia patients at diagnosis

9. Marta Zarà (Pavia): Platelet-derived microparticles as modulators of tumor metastatic potential

Ilaria Caon (Varese): The long non coding RNA HAS2-AS1 regulates breast cancer cells aggressiveness through a molecular sponge effect

Raffaella Longo (Milano): Ablation of epigenetic modifier histone deacetylase 3 in adipose tissue highlights chromatin acetylation as integral part of metabolism

Giulia Mancini (Milano): Effects of sphingolipids on membrane chloride channel stabilization in bronchial epithelial cell lines: a new challenge for the cystic fibrosis therapy

Emanuela Stampone (Napoli): p57^Kip2 in cell biology: focus on its post-translational modifications

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POSTER SESSION B, THURSDAY, JUNE 8^th, h 17:20-19:00*

1. Elena Bruzzone (Firenze): The role of GPR37 receptor in neurodegenerative diseases

2. Livia Cabitta (Milano): Identification of the antigen recognized by rHIgM22, a remyelination-promoting human monoclonal antibody

3. Maria Elena Canali (Milano): The role of sialidase Neu3 in the cardiac response to ischemia and reperfusion injury

4. Chiara Manega (Milano): 12-HETE in atherosclerotic disease: role in the efferocytic process

5. Alice Franchi (Genova): A new compound isolated from olive pomace extract protects cells from calcium-mediated damages

6. Anjali Gaur (Pavia): Preliminary observations on the rate of conversion of protein 4.1b to 4.1a in human red blood cell ghosts incubated in vitro depending on temperature and pH

7. Antonino Martines (Genova): Specific role of the Ca²⁺-dependent protease calpain-1 resident in membrane lipid rafts

8. Matteo Trande (Verona): Biophysical and structural characterization of neuronal calcium binding protein 1, NECAB1

9. Elettra Sereni (Firenze): Study on cellular and molecular mechanisms underlying the biological effects of extremely low frequency electromagnetic fields (ELF EMFS)

Paolo La Rocca (Milano): Synthesis, purification and biological activity evaluation of some unsaturated sialic acid derivatives as sialidase inhibitors

Matteo Miceli (Milano): Shedding new light on the endocannabinoid system: fluorescent assays for monoacylglycerol lipase (MAGL)

Roberto Spezzano (Milano): SCA38 pathology: study in the ELOVL5 KO mouse model and in patients

Suresh Velnati (Novara): Novel diacylglycerol kinase alpha inhibitors for X-linked lymphoproliferative disease 1 therapy

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*Only posters with number will be presented orally.

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