31^a Riunione Nazionale
"A. Castellani"
dei Dottorandi di Ricerca in
Discipline Biochimiche

(31^st “A. Castellani” Meeting of PhD students in biochemical sciences)

SCIENTIFIC AND ORGANIZING COMMITTEE

Cesare Balduini
Vittorio Bellotti
Ilaria Canobbio
Gianni Francesco Guidetti
Giampaolo Minetti
Chiara Paganini
Maria Enrica Tira
Francesca Tonelli
Mauro Torti
Maurizia Valli 
Mauro Magnani
Raffaele Porta
Annalisa Santucci 

 SCIENTIFIC AND ORGANIZING SECRETARIAT

Università degli Studi di Pavia

Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”

Laboratori di Biochimica

Via A. Bassi, 21 - 27100 PAVIA

 Tel. 0382/987236 - Fax 0382/987240

E-mail: riundott@unipv.it  - Homepage: http://www.unipv.it/bralweb

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PROGRAM

MONDAY, JUNE 3^rd, 2019

17.00-20.00 ARRIVAL AND REGISTRATION

20.00 DINNER

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TUESDAY, JUNE 4^th, 2019

8.50-9.00 OPENING OF THE MEETING

Chair:    Vittorio Bellotti

9.00-9.40 Prof. LUIGI PALMIERI (Bari)    
Mitochondria and aging

9.40-10.00 Francesco Capriglia (Bari)
Elucidating the molecular mechanisms underlying the biological activity of rescuing peptides in MELAS mitochondrial disease

10.00-10.20 Laura Ioannilli (Roma)
FoxO1 in the mitochondria of adipose tissue: impact on cell response to nutrient availability

COFFEE BREAK

Chair:

10.50-11.10 Maria Tolomeo (Bari)
Alteration of flavin homeostasis in neuromuscular disorders and cancer

11.10-11.30 Roberta Cavagna (Milano)
Capture next generation sequencing enhances the identification of clonal rearrangements as markers in acute lymphoblastic leukemia patients

11.30-11.50 Maddalena Cagnone (Pavia)
A pilot study to investigate the balance between proteases and α1-antitrypsin in lung transplant patients

11.50-12.10 Jessica Canino (Pavia)
Role of proline-rich tyrosine kinase Pyk2 in thromboinflammation

LUNCH

Chair:

15.00-15.40 Prof. FEDERICO BUSSOLINO (Torino)
Transcription factor EB reprograms tumor microenvironment by a lysosomal/autophagy -independent pathway

15.40-16.00 Chiara Maria Manega (Milano)
12(S)-hydroxyeicosatetraenoic acid downregulates monocyte-derived macrophage efferocytosis: new insights in atherosclerosis

16.00-16.20 Alice Franchi (Genova)
Bioactive molecules isolated from olive pomace extract protect murine cortex neurons from NMDA-mediated cell death

COFFEE BREAK

17.00-19.00 POSTER PRESENTATION FOLLOWED BY POSTER VIEWING - SESSION A
Authors should place their posters on the provided boards and present them in front of the audience with 2-3 slides for a total of 5 min including discussion.

DINNER

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WEDNESDAY, JUNE 5^th, 2019

Chair:

9.00-9.40 Prof. FABRIZIO TAGLIAVINI (Milano)
Molecular subtypes of Alzheimer's disease

9.40-10.00 Giulia Faravelli (Pavia)
Using Caenorhabditis elegans and INVAPP/Paragon automated system for amyloid drug screening

10.00-10.20 Rebecca Piccarducci (Pisa)
α-synuclein heterocomplexes in red blood cells as potential diagnostic biomarkers in Alzheimer’s disease

COFFEE BREAK

Chair:    

11.00-11.20 Erika Di Biase (Milano)
The oligosaccharide of GM1 ganglioside acts as a neurotrophic agent for neuronal development

11.20-11.40 Giovanna Menduti (Roma)
Response to oxidative stress of neuronal cells overexpressing ALDH5A1 gene variants

11.40-12.00 Giulia Lunghi (Milano)
GM1 oligosaccharide modulation of calcium signaling in neuronal functions

LUNCH

Chair:

15.00-15.40 Prof. FRANCESCO BONOMI (Milano)
Nanoparticles and solid systems: their effects on protein structure and function

15.40-16.00 Valentina Bordoni (Sassari)
Artemisia silver nanoparticles: new opportunities to fight cancer

16.00-16.20 Michela Lapi (Milano)
Biochemical and structural characterization of Nuclear Factor I X (NFIX)

COFFEE BREAK

 

17.30-18.30 Dottorandi di Pavia
Il lato oscuro della ricerca biomedica

20:00        DINNER

    

21.00-23.00 Serata caminetto
Luca Vanzago e Raffaele Porta:
Un colloquio tra Biochimica e Filosofia

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THURSDAY, JUNE 6^th, 2019

Chair:    

9.00-9.40 Prof. MARCO MORACCI (Napoli)
Discovery of carbohydrate active enzymes from (hyper)thermophiles: how to exploit natural diversity in biotechnology

9.40-10.00 Maria Elena Laugieri (Genova)
Study and characterization of glycosyltransferases from Paramecium bursaria Chlorella virus–1

10.00-10.20 Maria Elena Canali (Milano)
The role of sialidase NEU3 in the cardiac response to ischemia and reperfusion injury

COFFEE BREAK

Chair:    

11.00-11.40 Prof. LARS KAESTNER (Saarbrücken)
Something (new) about proteins and cells

11.40-12.00 Francesca Grassi Scalvini (Milano)
Proteomic and behavioural analysis of thermal stress effects on Zebrafish brain

LUNCH

Chair:    

15.00-15.40       Prof. RAFFAELE PORTA (Napoli)
                          Plastics revolution, pollution and substitution

                           Prof. MOHAMMED SABBAH (Napoli)
                           Polysaccharide and protein-based bioplastics

15.40-16.00 Ferdinando Sansone (Napoli)
Characterization of a new beta-galactosidase from thermophilic Bacillus coagulans strain MA-13 for biotechnological applications

16.00-16.20 Vittoria Cicaloni (Siena)
Interactive Alkaptonuria Database: investigating clinical data to improve patient care

COFFEE BREAK

17.00-19.00 POSTER PRESENTATION FOLLOWED BY POSTER VIEWING - SESSION B
Authors should place their posters on the provided boards and present them in front of the audience with 2-3 slides for a total of 5 min including discussion.

DINNER

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FRIDAY, JUNE 7^th, 2019

Chair:    

9.30-10.10 Prof. ANNALISA SANTUCCI (Siena)
Alkaptonuria: the history, the story and the research on the first human genetic disease

10.15 CLOSING REMARKS

 

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COFFEE BREAK and DEPARTURE

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POSTER SESSION A, TUESDAY, JUNE 4^th 2019, 17:00-19:00  

1. Mariangela Jessica Alfeo (Pavia): Iron-regulated surface determinant B (IsdB) mediates Staphylococcus aureus adherence to vascular endothelium through von Willebrand factor (vWF)

2. Ilaria Artusi (Padova): The extracellular EpiP serine protease from Staphylococcus aureus proteolytically activates prothrombin and triggers blood coagulation: implications in septic thrombosis

3. Stefano Barbera (Siena): Rab5C regulates the CD93/Multimerin-2/b1 integrin complex trafficking during endothelial cell adhesion and migration

4. Serena Castelli (Roma): Pseudo-hypoxia induction by Adipose Triglyceride Lipase (ATGL) in Hela cells

5. Francesca Maria Castiglia (Siena): Synthesis, efficacy and cytotoxicity of the antimicrobial peptide SET-M33: analysis of the best counter ion

6. Carmela Piazzolla (Bari): Role of mitochondrial uncoupling protein-2 in pancreatic ductal adenocarcinoma tumorigenesis and maintenance

7. Deborah Pietrobono (Pisa): Adenosine promotes glioblastoma aggressiveness modulating the epithelial-mesenchymal transition

8. Simona Saporiti (Milano): IgG1 effector functions: elucidation of glycans role by in silico structural analysis

9. Paolo Maria Soprano (Pavia): Exploiting natural silk protein for bioengineering bone marrow niche for ex vivo platelet generation

10. Mauro Vismara (Pavia): Analysis of the effects of platelet-derived microparticles on a breast cancer cell line

11. Carolina Zara (Urbino): Increase of intracellular glutathione (GSH) by I-152, a conjugate of N acetyl-cysteine (NAC) and β-mercaptoethylamine (MEA)

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POSTER SESSION B, THURSDAY, JUNE 6^th, h 17:00-19:00  

1. Clementina Barone (Napoli): Characterization of p57^kip2/CDNK1C mutations identified in Beckwith-Wiedemann syndrome

2. Luca Bombardi (Verona): Molecular and structural properties of centrin 2 from Toxoplasma gondii

3. Tatiana Carrozzini (Milano): Protective effects of coffee metabolites against oxidative stress

4. Silvia Cotti (Pavia-Ghent): The effects of phosphorous deficiency and oversupply: vertebral column malformations and bone mineralization in wild-type and osteogenesis imperfecta zebrafish mutants

5. Federico D’Alessio (Roma): Characterization of YggS, a protein involved in pyridoxal 5’-phosphate transport and homeostasis

6. Nadia Garibaldi (Pavia): Cellular homeostasis in murine osteoblasts from two osteogenesis imperfecta models is rescued by phenylbutyric acid

7. Laura Leoni (Pavia): Characterization of OI type XIV zebrafish models

8. Sonia Spinelli (Genova): ABA stimulates insulin-independent glucose uptake in L6 rat myoblasts and in mouse skeletal muscle via AMPK activation

9. Giovanni Stelitano (Pavia): Targeting iron uptake pathway for the development of novel antitubercular drugs

10. Filippo Tasini (Urbino): Characterization of the ubiquitin system in primary and metastatic gastric cancer cell lines

11. Elisa Vignali (Varese): A new bacterial lignin peroxidase: recombinant overexpression and biotechnological applications

12. Daniela Cristina Vuoso (Napoli): Anticancer activity of Annurca apple polyphenol extract in triple negative breast cancer cells is mediated by ROS/JNK signaling axis

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