28^a Riunione Nazionale
"A. Castellani"
dei Dottorandi di Ricerca in
Discipline Biochimiche

SCIENTIFIC AND ORGANIZING COMMITTEE

Cesare Balduini

Anna Maria Bardoni

Federico Bussolino

Ilaria Canobbio

Antonella Forlino

Pier Luigi Martelli

Giampaolo Minetti

Andrea Mozzarelli

Maria Enrica Tira

Livia Visai

 SCIENTIFIC AND ORGANIZING SECRETARIAT

Università degli Studi di Pavia

Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”

Laboratori di Biochimica

Via A. Bassi, 21 - 27100 PAVIA

 Tel. 0382/987236 - Fax 0382/987240

E-mail: riundott@unipv.it  - Homepage: http://www.unipv.it/bralweb

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PROGRAM

MONDAY 6 JUNE 2016

17.00-20.00 ARRIVAL AND REGISTRATION

20.00 DINNER

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TUESDAY 7 JUNE 2016

9.20-9.30 OPENING OF THE MEETING

9.30-10.10 Prof. MATTEO T. DEGIACOMI (Oxford, UK)
Molecular dynamic simulation of protein folding and misfolding

10.10-10.30 Eisabetta Galanti (Milano)
Deeping into the structural and functional features of selected putative proteins sequences using a cell free protein system: the example of the GHIPs-like proteins from Arabidopsis thaliana.

10.30-10.50 Sara Grassi (Milano)
Identification of the antigen recognized by rHIgM22, a remyelination-promoting human monoclonal antibody.

COFFEE BREAK

11.20-11.40 Elena Maresi (Verona)
Determinants of substrate specificity and biochemical properties of ornithine aminotransferase from Toxoplasma gondii.

11.40-12.00 Maura Samarani (Milano)
Lysosomal dysfunction and neuronal damage in lysosomal storage disorders: possible role of altered sphingolipid metabolism.

12.00-12.20 Margherita Maggioni (Milano)
Neu5Ac-GgOse₄, the GM1 ganglioside oligosaccharide, induces neuritogenesis and activates phosphorylation of TrkA receptor in mouse neuroblastoma cells.

LUNCH

15.00-15.40 Prof. ANDREA MOZZARELLI (Parma).
Enzyme Inhibition: complementary computational and experimental tools

15.40-16.00 Benedetta Guidi (Milano)
Biocatalytic approach to the preparation of pramipexole.

16.00-16.20 Alessio Gamba (Milano)
Why the same disease can be originated by different genes? Protein complexes as cause of locus heterogeneity.

COFFEE BREAK

17.00-18.30 POSTER PRESENTATION FOLLOWED BY POSTER VIEWING - SESSION A
Authors should place their posters on the provided boards and present them in front of the audience with 2-3 slides for a total of 5 min including discussion.

DINNER

21.00-23.00 Meeting with Angelo Parini and discussion with the students on the topic:
Misconduct in science: ethical and socio-economic implications

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WEDNESDAY 8 JUNE 2016

 

9.00-9.40 Prof. CHIARA RIGANTI (Torino)
The multifaceted metabolism of cancer cells: is the Warburg effect always valid?

9.40-10.00 Alessandra Iscaro (Firenze)
Microenvironmental control of immune modulation sustains prostate carcinoma progression.

10.00-10.20 Matteo Paccagnella (Genova)
Production and study of diadenosine homodinucleotides to use as anticancer drugs.

COFFEE BREAK

11.00-11.20 Maria Petrosino (Roma)
Bromodomains and cancer epigenetics: consequences of naturally occurring missense mutations on their structure and function.

11.20-11.40 Fiorella Faggi (Brescia)
Caveolin-1 overexpression in the human embryonal rhabdomyosarcoma RD cells increases tumor growth and metastasis in vivo through a phospho-ERK-dependent signaling pathway.

11.40-12.00 Giulia Sara Ganzetti (Milano)
Use of genetically modified mice to study the anti-inflammatory and immunomodulatory role of high-density lipoproteins during atherosclerosis development.

12.00-12.20 Matteo Pellegrini (Genova)
Functional role of calpain-1 associated to NMDAR multiprotein complex of SKNBE neuroblastoma cells and adult rat hippocampus synaptosomes.

LUNCH

15.00-15.40 Prof. DAVIDE VIGETTI (Varese)
Hyaluronan: a simple molecule for different pathologies

15.40-16.00 Domitilla Schiumarini (Milano)
Role of the plasma membrane sphingolipid composition in inflammatory response to Pseudomonas aeruginosa infection in cystic fibrosis.

16.00-16.20 Susanna Fiorelli (Milano)
Heterogeneity of human monocyte-derived macrophages: a morpho-phenotypic study in patients with coronary artery disease.

COFFEE BREAK

 

DINNER

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THURSDAY 9 JUNE 2016

 

9.00-9.40 Prof. FRANCESCO BERNARDI (Ferrara)
Procoagulant and anticoagulant complexes in the initiation pathway: molecular bases of hemorrhagic and thrombotic diseases

9.40-10.00 Alessia Buso (Udine)
Different effects of immobility and rehabilitation on PGC1α-Sirt3 axis and oxphos protein expression in skeletal muscle of young and elderly men.

10.00-10.20 Margherita Bavestrello (Genova)
The activation of calpain and protein kinase C is involved in the abnormal release of matrix metalloproteinases 9 from cystic fibrosis peripheral blood.

COFFEE BREAK

11.00-11.20 Margherita Puppo (Genova)
TGF-β-dependent KSRP silencing is required to control multiple post-transcriptional programs during epithelial to mesenchymal transition.

11.20-11.40 Silvia Maruelli (Pavia)
Silencing RNA: approacing a treatment for classical Osteogenesis Imperfecta.

11.40-12.00 Matteo Audano (Milano)
Zc3h10 controls mitochondriogenesis and differentiation of skeletal muscle and adipose tissue.

LUNCH

15.00-15.40 Dr PAOLA STORICI (Trieste)
New trends in protein production for structural studies

15.40-16.00 Alessandra Perfetti (Milano)
Skeletal muscle and circulating microRNAs in myotonic dystrophy type 1.

16.00-16.20 Giulia Resmini (Milano)
Hypoxic pre-conditioning induces murine myoblasts skeletal muscle differentiation.

COFFEE BREAK

17.00-18.30 POSTER PRESENTATION FOLLOWED BY POSTER VIEWING - SESSION B
Authors should place their posters on the provided boards and present them in front of the audience with 2-3 slides for a total of 5 min including discussion.

DINNER

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FRIDAY 10 JUNE 2016

 

9.30-10.10 Prof. MARCO ERCOLE VANONI (Milano)
Systems Biology: post-genomic data, molecular networks and generation of emergent properties

10.15 CLOSING REMARKS

COFFEE BREAK and DEPARTURE

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POSTER SESSION A, TUESDAY, JUNE 7^th, h 17:00-18:30

1. Giuseppe Sirago (Bari): Protective effect of Growth Hormone Secretagogues (GHSs) in cisplatin-induced cachexia of rats: the involvement of mitochondria.

2. Caterina Visconte (Pavia): Role of amyloid precursor protein in platelet functionality.

3. Maria Cristina Barbalace (Bologna): Synergic protective effect of estrogens and sulforaphane against oxidative stress in cardiomyocytes.

4. Maria Arkel (Genova): Synthesis of new creatine derivatives for the treatment of the creatine deficiency disorders.

5. Aurora Diotallevi (Urbino): Expression of host stress markers following Leishmania infantum infection in a cell culture model.

6. Elisa Martino (Napoli): Biotechnological potential of purine nucleoside phosphorylase from archaea for prodrug activation in gene therapy.

7. Margherita Maggioni (Milano): Neu5Ac-GgOse₄, the GM1 ganglioside oligosaccharide, induces neuritogenesis and activates phosphorylation of TrkA receptor in mouse neuroblastoma cells.

8. Benedetta Guidi (Milano): Biocatalytic approach to the preparation of pramipexole.

9. Alessio Gamba (Milano): Why the same disease can be originated by different genes? Protein complexes as cause of locus heterogeneity.

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POSTER SESSION B, THURSDAY, JUNE 9^th, h 17:00-18:30

1. Michele Rossin (Verona): Chronic hypoxia induces dormancy in breast cancer cell line MDA-MB-231.

2. Antonino Martines (Genova): eNOS/HSP90/calpain-1 system inserted in caveolin-1 lipid raft is altered both in endothelial cell exposed to high glucose and in diabetic rats.

3. Sara Orazi (Urbino): Unexpected effect of Dexamethasone in ataxia telangiectasia cell lines.

4. Francesca Tonelli (Pavia): Generation of recessive Osteogenesis Imperfecta zebrafish models using CRISPR-Cas9 system.

5. Anjali Gaur (Pavia): Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance (RELEVANCE) - Marie Skłodowska-Curie Actions, Innovative Training Network.

6. Giulia Mancini (Milano): Sphingolipids as new molecular targets for CTFR plasma membrane stabilization in bronchial epithelial cell lines.

7. Paolo La Rocca (Milano): NEU5Ac derivatives as inhibitors of newcastle disease virus hemagglutinin-neuroaminidase glycoprotein.

8. Donatella Delle Cave (Napoli): S-adenosylmethionine inhibits breast cell line MCF-7 proliferation by promoting autophagy process.

9. Susanna Fiorelli (Milano): Heterogeneity of human monocyte-derived macrophages: a morpho-phenotypic study in patients with coronary artery disease.

10. Giulia Resmini (Milano): Hypoxic pre-conditioning induces murine myoblasts skeletal muscle differentiation.

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