27^a Riunione Nazionale
"A. Castellani"
dei Dottorandi di Ricerca in
Discipline Biochimiche

SCIENTIFIC AND ORGANIZING COMMITTEE

Cesare Balduini

Pietro Speziale

Rita Casadio

Loredano Pollegioni

Paola Bruni

Antonio Rossi

Alberto Spisni

Maria Enrica Tira

Mauro Torti

Monica Stoppini

Maurizia Valli

Anna Maria Bardoni

Ilaria Canobbio

Giampaolo Minetti

 SCIENTIFIC AND ORGANIZING SECRETARIAT

Università degli Studi di Pavia

Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”

Laboratori di Biochimica

Via A. Bassi, 21 - 27100 PAVIA

 Tel. 0382/987236 - Fax 0382/987240

E-mail: riundott@unipv.it  - Homepage: http://www.unipv.it/bralweb

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PROGRAM

                       MONDAY, JUNE 8^th, 2015

17.00-20.00   Registration & check-in

20.00              DINNER

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                       TUESDAY, JUNE 9^th, 2015

9.00-9.10       OPENING REMARKS

9.10-10.10     Prof. PAOLO BONALDO (Padova)
Collagen VI, a key extracellular regulator of skeletal muscle.

10.10-10.30   Giusi Giada Picceri (Urbino)
Nanoparticles of chitosan and modified cyclodextrin for the in vitro release of antioxidants, IDE and GSH, in human keratinocytes.

COFFEE BREAK

11.10-12.10   Prof. LUIGI PALMIERI (Bari)
Uncoupling the uncoupling proteins: biochemistry makes a come back.

12.10-12.30   Serena Maggio (Urbino)
Muscle-enriched miRNAs from circulating EVs are modulated in response to exercise.

LUNCH

15.00-16.00   Prof. ANGELO PARINI (Toulouse, France)
Ageing: a matter of heart?

16.00-16.20   Claudia Martelli (Roma)
Top-down proteomic platform to investigate paediatric brain tumours.

16.20-16.40   Guglielmo Verona (Pavia)
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis.

16.40-17.00   Claudia Gabucci (Urbino)
Erythrocytes as carriers of phenylalanine ammonia lyase for the enzyme replacement therapy of phenylketonuria in mice.

COFFEE BREAK

 

17.30-18.30   POSTER VIEWING - SESSION A

DINNER

21.00-23.00   Meeting with Angelo Parini and Massimo Zeviani: two successful Italian researchers working abroad.

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                       WEDNESDAY, JUNE 10^th, 2015

9.00-10.00     Prof. MASSIMO ZEVIANI (Cambridge, UK)
Mitochondria: from biology to pathology.

10.00-10.20   Serena Brundu (Urbino)
Thiol depletion, Th2 polarization and the possible role of pro-glutathione molecules as immunotherapeutics in murine AIDS.

COFFEE BREAK

10.50-11.50   Prof. MENICO RIZZI (Novara)
Macromolecular tools for the evolutionary success of Mycobacterium tuberculosis: structural and biochemical insights.

11.50-12.10   Laura Contardi (Parma)
Gemini bispyridinium surfactants as nonviral vectors for gene-delivery.

12.10-12.30   Simone Lauria (Milano)
A new fluorescence-based assay for inhibitor screening on monoacylglycerol lipase.

LUNCH

15.00-16.00   Prof. RAFFAELE PORTA (Napoli)
Transglutaminase... from polyamines to bioplastics.

16.00-16.20   Fabio Baroni (Parma)
Modelling leucine-rich repeats containing protein: a receptor for cerato platanins.

COFFEE BREAK

17.00-17.20   Daria Manganaro (Pavia)
Study on Vps34 involvement in amino acid sensing.

17.20-17.40   Maria Luisa D’Angelo (Varese)
A novel protein of c10orf118 synthesized by breast cancer cells: role in cell functions and hyaluronan metabolism.

DINNER

21.00-23.00   RAFFAELE PORTA, Biochemical Biotechnology and Enzymology (BBE) group, Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy.
Presentation of the book: Biolove – La biochimica dell’amore.

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                       THURSDAY, JUNE 11^th, 2015

9.30-10.30     Prof. ANDREA GRAZIANI (Novara/Milano)
New roles of Ghrelin, an orexygenic peptide hormone, in regulating muscle mass and regeneration.

10.30-10.50   Irving Donadon (Ferrara)
The hemophilia A frequent mutation p.R2016W affects coagulation factor VIII expression by affecting both pre mRNA splicing and protein biology.

COFFEE BREAK

11.30-11.50   Daniela Scalet (Ferrara)
Correction of aberrant splicing causing haemophilia B through the combination of compensatory U1snRNAs and antisense oligonucleotides.

11.50-12.10   Silvia Meneghetti (Ferrara)
Integrated approaches support a role for the proto-oncogene BCL3 in atherosclerosis.

12.10-12.30   Andrea Ilaria Zotti (Napoli)
Preclinical and phase II clinical study of the combination of cisplatin, cetuximab and valproic acid in head and neck squamous carcinomas.

LUNCH

15.00-16.00   Prof. ANDREA BELLELLI (Roma)
Thioredoxin reductase: analysis of kinetics and inhibition of a two-substrate enzyme, and some hints to avoid common pitfalls.

16.00-16.20   Lorenzo Cavallini (Firenze)
Role of miR-1247 in prostate cancer progression.

COFFEE BREAK

16.50-17.10   Valentina Murdica (Milano)
Effect of abiraterone and ionizing radiation on the glycohydrolase activities in prostate cancer cells.

17.10-17.30   Teresa Ricciardi (Urbino)
CLOCK gene related SNPs and miRNAs as potential survival biomarkers in female patients (pts) with metastatic liver colorectal cancer (mCRC).

 

17.45-18.45   POSTER VIEWING - SESSION B

DINNER

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 FRIDAY, JUNE 12^th, 2015

9.30-10.30     Prof. ANNA YU. BOGDANOVA (Zürich, Switzerland)
Calcium handling in red blood cells of sickle cell disease patients.

10.30              CLOSING REMARKS

 

 

 

                       COFFEE BREAK AND DEPARTURE

 

 

 

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POSTER SESSION A, TUESDAY, JUNE 9^th, h 17:30-18:30

1.        Giulia Signorino (Roma): Effects of the insertion of a neo-cassette in dystroglycan gene: analysis of mouse skeletal muscle.

2.        Silvia Maruelli (Pavia): A silencing approach to treat classical Osteogenesis Imperfecta.

3.        Giulia Nobile (Pavia): Studies on the specific interaction of human plasminogen with FnBPB, a fibronectin/fibrinogen-binding protein from Staphylococcus aureus.

4.        Tomas Di Mambro (Urbino): Design and humanization of a murine scFv antibody against β1,3 glucan of Aspergillus fumigatus.

5.        Giulia Sara Ganzetti (Milano): Use of genetically modified mice to study the anti-inflammatory and immunomodulatory role of high-density lipoproteins during atherosclerosis development.

6.        Maura Samarani (Milano): Lysosomal impairment in sphingolipidoses: exploring the molecular mechanisms involved in the onset of cellular damage.

7.        Margherita Maggioni (Milano): Wheat gluten exorphins A5 and C5 interaction and absorption through an in vitro model of intestinal epithelium, a preliminary study.

8.        Sara Grassi (Milano): Identification of the antigen recognized by rHIgM22, a remyelination-promoting human monoclonal antibody.

9.        Elisabetta Galanti (Milano): Glycoside hydrolase inhibitor proteins: biochemical features and molecular biology.

10.  Domitilla Schiumarini (Milano): Dissecting the role of the non-lysosomal β glucosylceramidase GBA2 in the inflammatory response to Pseudomonas aeruginosa in cystic fibrosis.

11.  Andrea Fagagnini (Verona): Extensive deamidation inhibits RNase A oligomerization through 3D domain swapping.

12.  Federica Pierucci (Firenze): Cardiac ECM remodeling elicited by relaxin requires sphingosine 1-phosphate formation.

13.  Teresa Ricciardi (Urbino): CLOCK gene related SNPs and miRNAs as potential survival biomarkers in female patients (pts) with metastatic liver colorectal cancer (mCRC).

14.  Alessio Gamba (Milano): Dynamic light scattering analysis of aggregation kinetics in A2T and A2V mutations of Aβ_1–42, from monomers to fibrils.

 

 

POSTER SESSION B, THURSDAY, JUNE 11^th, h 17:45-18:45

1.        Claudia Boldrini (Pisa): Mitochondrial protein lysine acetylation is promoted by palmitate treatment in rat INS-1E.

2.        Silvia Pignani (Ferrara): Creation of a mouse models of FVII deficiency carrying the human F7 promoter by CRISPR-Cas9.

3.        Mattia Ferrarese (Ferrara): Haemophilia B as model for the analysis of context-dependent suppression of nonsense mutations by ribosome readthrough.

4.        Margherita Bavestrello (Genova): Alterations of cystic fibrosis-PBMC induced by an increase in [Ca²⁺]_i.

5.        Matteo Pellegrini (Genova): A calpain-1 -HSP90 complex regulates NMDAR-mediated calcium entrance in neuroblastoma cell line.

6.        Sara Lusa (Napoli): Urotensin II-targeted liposomes as new targeted delivery system towards prostate and colon cancer cells.

7.        Hana Sustova (Novara): Positive effect of unacylated ghrelin on dystrophic muscle in vivo.

8.        Emanuela Agosti (Novara): Protective effects of unacylated ghrelin in aging mice.

9.        Francesca Testa (Milano): Plasma membrane sialidase NEU3 controls epithelial-mesenchymal transition in melanoma cells.

10.  Caterina Miceli (Firenze): Oleuropein aglycone induces autophagy through AMPK/mTOR signaling: a mechanistic insight.

11.  Nicole Finesso (Torino): Antimicrobial effects against MRSA and C. albicans of chitosan-shelled oxygen-loaded nanobubbles and nanodroplets.

12.  Leonardo Lorenzini (Pisa): Effect of thyroid hormones and 3-iodothyronamine on sirtuin expression and energy metabolism..

13.  Maria Cristina Nicolardi (Bari): Functional characterization and organ distribution of three mitochondrial ATP-Mg/P_i carriers in Arabidopsis thaliana.

 

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