26^a Riunione Nazionale
"A. Castellani"
dei Dottorandi di Ricerca in
Discipline Biochimiche

SCIENTIFIC AND ORGANIZING COMMITTEE

Cesare Balduini

Alberto Spisni

Federico Bussolino

Sandro Sonnino

Menico Rizzi

Pietro Speziale

Vittorio Bellotti

Giampaolo Minetti

Mauro Torti

Livia Visai

 SCIENTIFIC AND ORGANIZING SECRETARIAT

Università degli Studi di Pavia

Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”

Laboratori di Biochimica

Via A. Bassi, 21 - 27100 PAVIA

 Tel. 0382/987236 - Fax 0382/987240

E-mail: riundott@unipv.it  - Homepage: http://www.unipv.it/bralweb

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PROGRAM

                       MONDAY, JUNE 9^th, 2014

17.00-20.00   Registration & check-in

20.00              DINNER

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                       TUESDAY, JUNE 10^th, 2014

9.30-9.40       OPENING REMARKS

9.40-10.40     Prof. PAUL FRASER (Toronto)
Modeling Alzheimer Disease and Related Proteinopathies

COFFEE BREAK

11.10-11.30   Cristina Soria (Pavia)
Establishment of a C. elegans model to study amyloidogenesis of human β₂-microglobulin in vivo

11.30-11.50   Manuela Leri (Firenze)
Oleuropein aglycon: a natural polyphenol with inhibitory effects on toxicity by transthyretin fibrillogenesis

11.50-12.10   Fabio Baroni (Parma)
Probing the different biological activity of two cerato platanin family members through the NMR investigation of random coil regions

12.10-12.30   Marcello Ceccarelli (Urbino)
Detection and characterization of Leishmania (leishmania) and Leishmania (viannia) by SYBR Green-based real-time PCR and high resolution melt analysis targeting kinetoplast minicircle DNA

LUNCH

15.00-16.00   Prof. MARTINO BOLOGNESI (Milano)
Discovering antigens & epitopes through structural vaccinology

16.00-16.20   Maria Vetro (Milano)
Gold nanoparticles as carriers of Streptococcus pneumoniae carbohydrate antigens for fully synthetic vaccines

16.20-16.40   Federica Catalani (Genova)
Identification of anthracyclines produced by Streptomyces from soil by means of HPLC-MS and HR-MS techniques

COFFEE BREAK

17.00-18.00   POSTER SESSION A:
9 poster presentations, 5 min each
see below and Abstracts Book for details)

18.00-19.00   POSTER VIEWING - SESSION A

DINNER

21.00-23.00   GUIDO GRANDI (Novartis Vaccines & Diagnostics, Siena)
Informal conversation with the students:
Professional opportunities in biotechnology

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                       WEDNESDAY, JUNE 11^th, 2014

9.30-10.30     Prof. GUIDO GRANDI (Siena)
“Omics” in Vaccine Discovery and Immunotherapy

COFFEE BREAK

11.10-11.30   Maura Samarani (Milano)
The non-lysosomal β-glucosylceramidase GBA2 as a new player in the neuronal differentiation process

11.30-11.50   Federica Naso (Bologna)
Role of lipid peroxidation product in zebrafish development

11.50-12.10   Benedetta Porro (Milano)
Evaluation of L-arginine/nitric oxide metabolic pathway in erythrocytes in relation with oxidative stress: focus on coronary artery disease

12.10-12.30   Daria Manganaro (Pavia)
The interplay between Pyk2 and phosphatidylinositol 3-kinaseβ in GPVI signaling

LUNCH

15.00-16.00   Prof. MARGHERITA RUOPPOLO (Napoli)
Exploring inborn errors of metabolism through metabolomics and proteomics

COFFEE BREAK

16.40-17.00   Luca Monti (Pavia)
N-acetylcysteine treatment improves the disease phenotype in foetuses of a mouse model of diastrophic dysplasia

17.00-17.20   Valentina Murdica (Milano)
Effect of abiraterone and ionizing radiations on the glycohydrolase activities in prostate cancer cells

17.20-17.40   Xuqin Xie (Milano)
A complex between gangliosides and caveolin-1 regulates the adhesion of human ovarian cancer cells

17.40-18.00   Maria Castellano (Napoli)
SNALPs Delivery Pro-Apoptotic miR-34a Are Active in the Treatment of Multiple Myeloma

DINNER

21.00-23.00   PAUL FRASER (Jeno Diener Chair in Neurodegenerative Diseases, Tanz CRND, University of Toronto; Associate Editor of The Journal of Biological Chemistry)
Informal conversation with the students:
Impact factor, citations, journals reputation, editorial policy : how to choose the right journal for a biochemist?

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                       THURSDAY, JUNE 12^th, 2014

9.30-10.30     Prof. PAOLO BERNARDI (Padova)
From ATP to PTP: A new life (or death) for the mitochondrial ATP synthase?

COFFEE BREAK

11.10-11.30   Isabella Maiellaro (Bari)
Acetyl-L-carnitine prevents alteration of mitochondrial biogenesis, mitochondrial dynamics and mitochondrial antioxidant defenses  in the heart of old rat

11.30-11.50   Alessandra Ferrari (Milano)
Epigenetics of energy metabolism: focus on class I histone deacetylases

11.50-12.10   Dario Bonardi (Brescia)
Association of sialidase NEU3 to different membrane domains: dynamics, ganglioside degradation and signaling aspects

12.10-12.30   Giovanna Sociali (Genova)
A P2X7 antagonist improves muscle strength and motor distal amplitude in CMT1A rats: preliminary results from an in vivo trial

LUNCH

15.00-16.00   Prof. RITA CASADIO (Bologna)
Bioinformatics and Computational Biology in the post-genomic era

16.00-16.20   Giulia Biondani (Verona)
Characterization of cancer stem cells derived from pancreatic ductal adenocarcinoma cell lines and generation of three-dimensional culture models

16.20-16.40   Giuliano Stirparo (Milano)
Identification of temporally modulated lncRNA in cardiac hypertrophy

COFFEE BREAK

17.00-18.00   POSTER SESSION B:
9 poster presentations, 5 min each
see below and Abstracts Book for details)

18.00-19.00   POSTER VIEWING - SESSION B

DINNER

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 FRIDAY, JUNE 13^th, 2014

9.30-10.30     Prof. SABATA MARTINO (Perugia)
Stem cells for regenerative medicine applications

10.30              CLOSING REMARKS

                       COFFEE BREAK AND DEPARTURE

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POSTER SESSION A, TUESDAY, JUNE 10^th, h 17:00-18:00

1.        Debora Oro (Udine): Towards novel strategies to prevent prosthetic joint infection: the potential of α-helical antimicrobial peptides

2.        Concetta Paola Ilisso (Napoli): Synergistic effect of the methyl donor S-adenosylmethionine and doxorubicin in CG5 breast cancer cells

3.        Beatrice Maggiore (Ancona): Structural properties of bovine α₁-Acid glycoprotein

4.        Sara Grassi (Milano): Identification of the antigen recognized by IGM22, a remyelination-promoting human antimyelin monoclonal antibody

5.        Simone Lauria (Milano): Design of a new fluorogenic reporter in human monoacylglycerol lipase inhibition models

6.        Guglielmo Verona (Pavia): Understanding the role of proteolysis in transthyretin amyloidosis

7.        Valentina Gianotti (Pavia): High frequency invasion of CPEK cells by Staphylococcus pseudintermedius

8.        Amalia Di Petrillo (Cagliari): Inhibitory effects of 3-heteroarylcoumarin derivatives on the activity of tyrosinase

9.        Laura Schembri (Napoli): Physiological role of the mono-ADP-ribosyltransferase PARP12

10.  Elisa Ruffo (Novara): SAP-mediated inhibition of diacylglycerol kinase alpha regulates TCR-induced diacylglycerol signaling and restimulation-induced apoptosis in XLP patients

 

POSTER SESSION B, THURSDAY, JUNE 12^th, h 17:00-18:00

1.        Francesca Avemaria (Milano): Genetic variability in the Fructosamine 3-kinase gene promoter region in diabetic patients under stable glycemic control

2.        Francesco Cammarata (Milano): Clinical and biomolecular investigation of knee osteoarthritis

3.        Teresa Vitali (Milano): Human MICAL1, a multidomain flavoenzyme involved in actin cytoskeleton dynamics

4.        Claudia Corso (Verona): Oxidative conditions influence the interaction between peroxiredoxin-2 and the N-terminal cytoplasmic domain of band 3

5.        Luigi Ippolito (Firenze): Docetaxel resistance induces a respiratory phenotype correlated to EMT in prostate cancer

6.        Federica Naso (Bologna): Role of lipid peroxidation product in zebrafish development

7.        Alessandro Capo (Napoli): An optical biosensor for benzene detection

8.        Maria Luisa D’Angelo (Varese): Role of hyaluronan and the Q7z3e2 protein in human breast cancer cells

9.        Isabella Piga (Pisa): Comparative proteomics of native Tuscany cultivars of Olea europaea: a preliminary study

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