25^a Riunione Nazionale
"A. Castellani"
dei Dottorandi di Ricerca in
Discipline Biochimiche

COMITATO SCIENTIFICO ed ORGANIZZATORE

Cesare Balduini

Annarita Ciana

Chiara Cini

Bruno Giardina

Giampaolo Minetti

Alberto Spisni

Maria Enrica Tira

Mauro Torti

Livia Visai

 SEGRETERIA SCIENTIFICA ed ORGANIZZATIVA

Università degli Studi di Pavia

Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”

Laboratori di Biochimica

Via A. Bassi, 21 - 27100 PAVIA

 Tel. 0382/987236 - Fax 0382/987240

E-mail: riundott@unipv.it  - Homepage: http://www.unipv.it/bralweb

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PROGRAMMA

LUNEDÌ 10 GIUGNO 2013

17.00-20.00 REGISTRAZIONE

20.00 CENA

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MARTEDÌ 11 GIUGNO 2013

9.00-9.10 APERTURA DEI LAVORI

9.10-10.10 Prof. MIRKO PINOTTI (Ferrara)
Aberrant pre-mRNA splicing in coagulation factor deficiencies: from molecular mechanisms to RNA-based therapeutic approaches

10.10-11.10 Prof. VITO DE PINTO (Catania)
Intracellular pore-forming proteins: from discovery to protein engineering

COFFEE BREAK

11.40-12.00 Matteo Campioni (Ferrara)
Ribosome readthrough accounts for secreted full-length factor IX in hemophilia B patients with nonsense mutations

12.00-12.20 Giulia Pavani (Ferrara)
EPCR binding to factor VIIa enhances its hemostatic function in vivo

INTERVALLO PRANZO

15.00-16.00 Prof. MAURO S.G. PAVÃO (Rio de Janeiro)
The roles of proteoglycans and complex glycans during tumor cell invasion and metastasis

16.00-16.20 Alice Santi (Firenze)
Fibroblasts transfer lipids and proteins to tumor cells supporting their growth

COFFEE BREAK

16.50-17.10 Claudia Lentucci (Siena)
Snai1 role during embryonic stem cells differentiation

17.10-17.30 Tiziana Vigliarolo (Genova)
Abscisic acid transport in human erythrocytes

18.00-19.00 VISIONE POSTER - SESSIONE A
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 MERCOLEDÌ 12 GIUGNO 2013

9.00-10.00 Prof. FABIANA PASSARO (Napoli)
The essence of cellular senescence

10.00-11.00 Prof. SANDRO SONNINO (Milano)
Plasma membrane glycohydrolases and new strategies for medical diagnosis and therapeutic treatments

COFFEE BREAK

11.30-11.50 Valentina De Benedictis (Bari)
Cytochrome c oxidase disfunction in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin

11.50-12.10 Giulia Chiavegato (Verona)
The sesquiterpene CNP inhibits STAT3 phosphorylation through GSH depletion and induces cell death in DU145 cell line

12.10-12.30 Loubna Abdelhadi (Milano)
Pivotal role of sphingolipids on luteolin-induced apoptosis in human colon cancer cells

INTERVALLO PRANZO

15.00-16.00 Prof. ALBERTO SPISNI (Parma)
NMR in biochemistry

16.00-16.20 Giorgia Manzo (Cagliari)
Tri-dimensional characterization of the immunomodulatory peptide Plasticin-L1 as a tool to investigate its mode of action

COFFEE BREAK

16.50-17.10 Federico Abbiati (Milano)
LXR activation restores altered lipid pattern induced by diabetes in myelin sheath

17.10-17.30 Erika Fiorino (Milano) 
Histone deacetylases in the regulation of cholesterol 7α-hydroxylase gene: impact on cholesterol homeostasis

17.30-17.50 Antonio Gregorio (Milano)
Development, and synthesis of CMP-Neu5Ac analogue as potential inhibitors of GM3 synthase

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GIOVEDÌ 13 GIUGNO 2013

9.00-10.00 Prof. BRUNO GIARDINA (Roma)
Storia di una ricerca “curiosity driven” dall’Artico all’Antartico

10.00-10.20 Elisabetta Brioschi (Milano)
Integrated approaches for the functional validation of potential mitochondrial regulators

10.20-10.40 Angelica Miccolis (Bari)
Functional and structural characterization of human FAD synthase (isoform 2) and its mutant forms

COFFEE BREAK

11.10-11.30 Denise Corti (Firenze)
Modulation of PKM2 activity in HT29 chemoresistant cells

11.30-11.50 Lorenzo Depau (Siena)
High cancer selectivity produced by simultaneous targeting of HSPG and endocytic receptors

11.50-12.10 Eri Muto (Milano)
Phenolic extracts from extra-virgin olive oil impact immunomodulation on the inflamed intestinal epithelial cells

12.10-12.30 Simone Luti (Firenze)
Biological activity of cerato-platanins

INTERVALLO PRANZO

15.00-16.00 Prof. NIKOS KARAMANOS (Patrasso)
Targeting cancer at the level of matrix macromolecules

16.00-16.20 Lorenzo Ghezzi (Siena)
Secondary amyloidosis in alkaptonuria

COFFEE BREAK

16.50-17.10 Mauro Cerasi (Roma)
Exploring the interconnections between iron and manganese homeostasis in Salmonella enterica and their relevance in bacterial response to oxidative stress

17.10-17.30 Gaia Grassini (Roma)
Biochemical characterization of glutamic acid decarboxylase from Brucella microti

18.00-19.00 VISIONE POSTER - SESSIONE B
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VENERDÌ 14 GIUGNO 2013

9.00-10.00 Prof. ALBERTO PASSI (Varese)
How covalent modifications control enzymatic activity: hyaluronan synthase 2

10.00-10.20 Manuela Currao (Pavia)
Fibronectin, laminin and type IV collagen are key elements of sinusoid-associated megakaryocyte “niche” within bone marrow

10.20-10.40 Vittorio Abbonante (Pavia)
Discoidin domain receptor 1: a new modulator of megakaryocyte function in the bone marrow environment

 

10.40 Chiusura dei lavori

 

COFFEE BREAK e PARTENZA

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POSTER SESSIONE A

Alessio Fiascarelli (Roma)
(PA1) HUMAN SERINE HYDROXYMETHYLTRANSFERASE AS CHEMOTHERAPEUTIC TARGET: INHIBITORY ABILITY OF 3-BROMOPYRUVATE, A PROMISING ANTITUMORAL COMPOUND

Benedetta Rizzo (Bologna)
(PA2) CAVEOLAE/LIPID RAFTS ACT AS PLATFORMS FOR REGULATIONOF PROTEINS INVOLVED IN VEGF-INDUCED REDOX SIGNALINGIN HUMAN LEUKEMIA CELLS

Donatella Romaniello (Roma)
(PA3) STAT3-EGFR PATHWAY IN NEUROENDOCRINE PROSTATE CANCER: A CASE REPORT

Xuqin Xie (Milano)
(PA4) A COMPLEX BETWEEN GANGLIOSIDES AND CAVEOLIN-1 REGULATES THE ADHESION OF HUMAN OVARIAN CANCER CELLS

Vanessa D’Antongiovanni (Pisa)
(PA5) DEREGULATION OF PAR1 EXPRESSION AND SIGNALING IN A MESOTHELIOMA CELL LINE, NCI-H28, WITH HOMOZYGOUS DELETION OF THE β-CATENIN GENE

Maria Luisa D’Angelo (Varese)
(PA6) ROLE OF HYALURONAN AND TUMOUR-ASSOCIATED ANTIGEN IN HUMAN BREAST CANCER

Nora Bloise (Pavia)
(PA7) HUMAN OSTEOBLAST-LIKE CELLS PROLIFERATION UNDER LOW-LEVEL LASER IRRADIATION: AN IN VITRO STUDY

Martina Bonacini (Parma)
(PA8) EPIGENETIC REGULATION OF CLUSTERIN TRANSCRIPTIONAL VARIANTS IN PCa CELL LINES

Marco Vercellino (Pavia)
(PA9) THE EFFECT OF CLUSTER ASSEMBLED TIO2 MODIFIED GLASS ON HUMAN BONE MARROW MESENCHYMAL STEM CELL PROLIFERATION AND OSTEOGENIC DIFFERENTIATION

Elisa Zappelli (Pisa)
(PA10) PURINERGIC AND CYSTEINYL-LEUKOTRIENE AGONISTS OF THE GPR17 RECEPTOR ENGENDER DISTINCT INTRACELLULAR SIGNALLING PROGRAMS WITH DIFFERENT FUNCTIONAL POTENTIALS

Nara Liessi (Genova)
(PA11) ROLE OF HIGH MOBILITY GROUP BOX 1 (HMGB1) PROTEIN ON NATURAL KILLER CELL ACTIVITY

Alessandra Ferrari (Milano)
(PA12) CLASS I HISTONE DEACETYLASES AS KEY EPIGENETIC REGULATORS OF ENERGY METABOLISM

Riccardo Donzelli (Pisa)
(PA13) QUANTIFICATION OF TISSUE T3 AND T4 IN RAT AND HUMAN HEART BY A NOVEL HPLC-MS/MS METHOD

Andrea Berardi (Milano)
(PA14) STRUCTURAL CHARACTERIZATION OF THE INTERACTION BETWEEN THE PHD5-C5HCH TANDEM DOMAIN OF NSD1 AND THE C2HR ZINC FINGER MOTIF OF NIZP1

POSTER SESSIONE B

Lorenzo Ghezzi (Siena)
(PB1) SAA FRAGMENTATION OF SECONDARY AMYLOIDOSIS: A MASS-SPECTROMETRY STUDY

Lorenzo Ghezzi (Siena)
(PB2) SECONDARY AMYLOIDOSIS IN ALKAPTONURIA

Donatella Galgano (Siena)
(PB3) IFT20 INTERACTS WITH ENDOSOMAL RABS TO CONTROL TCR RECYCLING AND IMMUNE SYNAPSE ASSEMBLY IN CONCERT WITH IFT52 AND IFT57

Alex Gregorelli (Verona)
(PB4) ANTI-INFLAMMATION ACTION OF ARACHIDONOYL AMIDE DERIVATIVES IN A HUMAN KERATINOCYTES CELL LINE MODEL OF ACUTE INFLAMMATION

Alexander Rudov (Urbino)
(PB5) ANTI-INFLAMMATORY AND PRO-APOPTOTIC ACTIVITY OF PLANT EXTRACTS

Maria Vetro (Milano)
(PB6) EVALUATION OF THE BIOCHEMICAL AND BIOLOGICAL ACTIVITY OF SULFOGLYCOLIPIDS TARGETING PROTEIN KINASE B (AKT)

Elena Casarano (Udine)
(PB7) MOLECULAR MECHANISMS OF NEURONAL RESPONSE TO OXIDATIVE STRESS INVOLVING THE NON CANONICAL DNA REPAIR PROTEIN APE1/Ref-1

Gianluca Conti (Varese)
(PB8) EVOLUTION OF A CEPHALOSPORIN C ACYLASE FOR INDUSTRIAL APPLICATIONS

Marselina Arshakyan (Urbino)
(PB9) CHARACTERIZATION OF THE GENE OF LYSINE SPECIFIC DEMETHYLASE 1 (LSD1) IN TUBER MELANOSPORUM

Anna Pennacchio (Napoli)
(PB10) SPR-BASED SENSING FOR PATULIN DETECTION

Alessia Parroni (Roma)
(PB11) PYRIDOXAL IS BOTH A SUBSTRATE AND AN INHIBITOR OF E. COLI PYRIDOXAL KINASE

Francesco Piacente (Genova)
(PB12) MIMIVIRUS ENCODES THE PATHWAY FOR THE BIOSYNTHESIS OF UDP-N-ACETYLGLUCOSAMINE

Lucia Radici (Urbino)
(PB13) YY1 SECOND LIFE: A DUAL ROLE IN MODULATING UBIQUITIN C GENE EXPRESSION AND SPLICING

Chiara Giacomelli (Pisa)
(PB14) THE BINDING FEATURES OF COPPER(II) TO ANGIOGENIN: POTENTIAL BIOLOGICAL IMPLICATION

Martina Iannaccone (Napoli)
(PB15) ANALISYS OF A NEW ISOFORM OF TRANSGLUTAMINASE IN THE NERVOUS SYSTEM

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